Tag Archives: Featured

Palliative care: The other opioid issue

When pharmacologist Ravindra Ghooi learned in 1996 that his mother had terminal breast cancer, he began to investigate whether he could obtain morphine, in case she needed pain relief at the end of her life. But a morphine prescription in India at that time, even for the dying, was a rare thing: most states required four or five different licences to buy painkillers such as morphine, and there were harsh penalties for minor administrative errors. Few pharmacies stocked opioids and it was a rare doctor who held the necessary paperwork to prescribe them. Ghooi, who is now a consultant at Cipla Palliative Care and Training Centre in Pune, used his connections to ask government and industry officials if there was a straightforward way of obtaining morphine for his mother. “Everybody agreed to give me morphine,” he recalls, “but they said they’d give it to me illegally.”

Read the rest of this feature in Nature Outlook: [html] [pdf].

Unburying the Spanish Civil War

In a waist-high trench alongside Spain’s national Highway 1, a dozen volunteers wearing rubber gloves brush tan clay from crumbling human bones. Their knees rest on foam cushions, and a white tent shades them from the summer sun. It’s July 2011—a full 75 summers after Spain erupted in the Civil War that put the bones of 59 civilians in the ground here.

A few steps away from the trench, volunteers hold microphones up to the murmuring mouths of elders from the town of Gumiel de Izán, in the north-central region of Castilla y León. The elders, who harbor memories of summary executions at the site, may well be the younger siblings, neighbors, and children of those in the grave. But at the moment of exhumation, nobody knows for sure. Instead, the volunteers document and collect the physical remains, coaxing out and recording imperfect memories that were suppressed during four decades of dictatorship.

Such sites are scattered throughout Spain, from the Canary Islands to La Mancha to the Balearic Islands. Recent estimates suggest that some 2,000 mass graves may hold the remains of up to 150,000 victims of hasty wartime executions.

Read the full feature in Sapiens: [html]  [pdf].
It is also syndicated to Scientific American: [html] [pdfand Scientific American en Español: [html] [pdf].

India’s energy subsidy slowdown

The hum of Gurumoorthy Sethuraman’s 10-horsepower (7.46 kW) irrigation pumps joins the murmur of nearby rivers in Arayapuram, India. Sethuraman, an experienced and successful farmer, plants alternating crops of rice and pulses each year in the southeast Indian state of Tamil Nadu. This bounty has enabled his family to send several of his grandchildren to study abroad in the United States and United Kingdom. Yet, by law, he and other commercial agriculture enterprise owners are not required to pay the utility that powers the 60 or so wells that irrigate his 15 hectares of land.

Sethuraman is representative of the fortunate few around the world —the International Monetary Fund reported in 2013 that the top 40% of the population in most developing countries received six times the energy subsidy received by the bottom 40% (http://go.nature.com/w1qdII). In the short run, he and others are direct beneficiaries, but in the long run, misdirected energy subsidies undermine economic development, according to economists at the International Energy Agency (http://go.nature.com/rPzFNR), the World Bank (http://go.nature.com/RJMxmO) and the International Monetary Fund (http://go.nature.com/E2wjfP). Such policies amount to an undeclared regressive tax that undermines investment in infrastructure, health and education for the poorest citizens. Of 40 countries examined during a Council on Foreign Relations workshop last year, for example, the average energy subsidy approached 30% of government revenue and was often greater than health or education spending (http://go.nature.com/pt37o7).

Yet India is in the midst of an energy subsidy reform. It began reducing its own energy subsidies in 2010 and has earned outside recognition for its progress so far (http://go.nature.com/qAbZkw). Its path to an energy policy that supports its poorest people will be long and complex, but it may now be experiencing a remarkable moment of opportunity to widen access to energy.

Read the full feature in Nature Energy: [html] [pdf].

Will Europe toast GM wheat for gluten sufferers?

Soon, individuals with celiac disease in southern Spain will begin receiving regular allotments of bread. Rather than misguided charity, this will be a clinical trial of a new type of dough made from genetically modified (GM) wheat. The wheat has been altered to be low in gliadins—the portion of gluten proteins that are toxic to people with celiac disease. If successful, the trial could bolster growing research efforts to engineer wheat to be compatible with the immune systems of the ~1% of the global population with celiac disease and the much larger number of people with gluten allergies.

Low-gluten wheat could also open a new front in the battle for GM food acceptability in Europe. If Europeans are ever going to accept a GM food, celiac-safe wheat may be a good candidate. European consumers accounted for over euro1.1 ($1.21) billion of nearly euro1.9 billion worldwide gluten-free food market, according to market research firm Euromonitor International. Global gluten-free bakery sales are expected to grow at >7% annually, the firm predicts. But because this and other efforts to modify wheat involve inserting genetic elements to silence genes, they are subject to a European regulatory process closely tied to anti-GM politics. And even if such legal barriers to marketing are overcome, marketing such a wheat would require not just farmers, but millers, bakers and consumers to be persuaded that it is worthwhile.

Read the rest of this feature in Nature Biotechnology: [html] [pdf].
También publicado en Scientific American en Español: [html] [pdf].